Published on May 2020 | Organic Synthesis, Sustainable Chemistry
A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-10 H-spiro[pyrazolo[4,3-f]quinoline-8,50 -pyrimidine]-20 ,40 ,60 (30 H)-triones (d.r. up to 20 : 1 (syn : anti)) and tetrahydro-8H-pyrazolo[4,3-f]pyrimido[4,5-b]quinoline-8,10(9H)-diones via formation of selective multiple C–C bonds under identical reaction conditions (viz. ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated. Both approaches involve mild reaction conditions, use of non-hazardous solvents, and facilitate good to excellent reaction yields of the target compounds.